• Polyphenols, naturally occurring substances found in plant-based foods and drinks, including fruits, vegetables, whole grains, tea, and red wine, have been recognized for their health benefits. Studies show that polyphenols, due to their anti-inflammatory properties, can counteract tumor growth. Additionally, polyphenols can form complexes with metals, such as copper, which is closely linked to cancer initiation and progression. Recent study focused on hydroxytyrosol, a derivative of oleuropein found in the Olea europaea plant, to explore its ability to form complexes with copper and potentially hinder the progression of triple-negative breast cancer, the most aggressive subtype lacking targeted therapy.

  • In a study published in Nutrients, hydroxytyrosol (htyr), tyrosol (tyr), and oleocanthal (ole) in extra virgin olive oil (EVOO) were investigated for their effects on cell proliferation, migration, antigenic profile, and cell cycle. Results showed a significant increase in cell proliferation with all compounds tested, particularly with htyr, tyr at higher doses, and ole at specific concentrations.

  • Hydroxytyrosol (HT) is mostly found in olive leaves following oleuropein hydrolysis. Other than its antioxidant, cardioprotective, anti-inflammatory, antibacterial, and neuroprotective characteristics, it has shown anti-depressive activity as the major chemical in olive leaves due to its possible capacity to penetrate the blood-brain barrier (BBB).