Hydroxytyrosol, Tyrosol, and Oleocanthal in Extra Virgin Olive Oil helps in wound healing

In a study published in Nutrients, hydroxytyrosol (htyr), tyrosol (tyr), and oleocanthal (ole) in extra virgin olive oil (EVOO) were investigated for their effects on cell proliferation, migration, antigenic profile, and cell cycle. Results showed a significant increase in cell proliferation with all compounds tested, particularly with htyr, tyr at higher doses, and ole at specific concentrations. Additionally, these compounds stimulated the expression of fibronectin and α-actin, enhancing cell migration without affecting the cell cycle. These findings suggest that the phenolic compounds in EVOO potentially contribute to wound healing by positively impacting fibroblast activity related to tissue regeneration.


The study highlighted the vital role of fibroblasts in wound healing, particularly in the phases of proliferation and remodeling. Fibroblasts participate in extracellular matrix formation, impacting cellular processes like adhesion, migration, and proliferation. They can differentiate into myofibroblasts, crucial in inflammation and tissue contraction post-injury. The paper emphasized how bioactive compounds in certain plant sources, such as phenolic compounds in EVOO, might stimulate fibroblast activity, promoting wound healing. EVOO's composition includes various phenolic compounds, with htyr, tyr, and ole being predominant. These compounds possess antioxidant properties and have shown diverse health benefits beyond wound healing, including anti-inflammatory, antimicrobial, and regenerative effects.


While previous studies have highlighted the antioxidant nature of these phenolic compounds, this research focused on their potential effects on tissue regeneration. The results indicated that htyr, tyr, and ole increased fibroblast proliferation, migration, and the expression of key markers involved in wound healing, without impacting the cell cycle. However, the mechanisms behind these effects, such as antioxidant, anti-inflammatory, and antibacterial properties, require further investigation. Understanding these mechanisms could pave the way for new therapeutic approaches for wound treatment, leveraging the benefits of EVOO-derived phenolic compounds to enhance healing processes.




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